天津地区帕金森病患者GRIN2A、GRIN2B基因rs4998386位点多态性观察

被引：0
|
作者：
肖颖 [1 ]
张本恕 [1 ]
机构：
[1] 天津医科大学总医院神经内科
来源：
山东医药 | 2022年 / 20期
关键词：
帕金森病; 谷氨酸盐受体; GRIN2A基因; GRIN2B基因; 基因多态性; 天津地区;
D O I：
暂无
中图分类号：
R742.5 [震颤麻痹综合征];
学科分类号：
1002 ;
摘要：
目的 观察天津地区帕金森病（PD）患者GRIN2A、GRIN2B基因rs4998386位点多态性情况。方法 选择PD患者104例纳入PD组，同期门诊查体健康者110例纳入对照组，两组为天津地区汉族人群。应用聚合酶链反应—限制性片段长度多态性分析技术观察两组GRIN2A基因rs4998386位点T/C多态性和GRIN2B基因rs4998386位点T/G多态性，计算两位点基因型和等位基因分布频率。结果 PD组GRIN2A基因rs4998386位点T等位基因和TC基因型分布频率高于对照组（P均<0.05）。两组GRIN2B基因rs4998386位点T/G各等位基因和基因型分布频率差异无统计学意义（P均>0.05）。结论 GRIN2A基因rs4998386位点T等位基因和TC基因型可能与天津地区PD的遗传易感性有关；而GRIN2B基因rs4998386位点T/G多态性可能与PD的发病关联性不大。
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页码：57 / 59
页数：3
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