碳酸酐酶抑制剂U-104通过CA9和CA12抑制舌鳞状细胞癌的进程（英文）

被引：0
|
作者：
杨紫暄 [1 ]
张雪寒 [1 ]
申涛 [1 ]
施荣华 [2 ]
汪香婷 [1 ]
机构：
[1] 中国科学技术大学生命科学与医学部
[2] 中国科学技术大学生命科学学院综合仪器实验中心
来源：
中国科学技术大学学报 | 2021年 / 51卷 / 05期
关键词：
碳酸酐酶抑制剂; U-104; CA9; CA12; 舌鳞状细胞癌;
D O I：
暂无
中图分类号：
R739.86 [舌肿瘤、舌下肿瘤];
学科分类号：
摘要：
U-104是一类高效的碳酸酐酶(CA)抑制剂,有望作为潜在的抗肿瘤药物应用于少数几类肿瘤的治疗.然而,U-104的下游机制及其在舌鳞状细胞癌中的功能尚不明确;其抗肿瘤效果是否依赖于CA9和CA12也未被证明.在本工作中,我们通过RNA测序发现了受U-104调节的差异表达基因和U-104可能影响的细胞内生物过程.在差异基因的富集分析中,排名位于前列的生物学过程包括与细胞死亡相关、细胞增殖、迁移和药物反应等生物学过程;这与我们利用U-104处理TSCC15舌癌细胞后观察到的生物学效应一致.进一步地,干扰CA9或CA12的表达完全消除了U-104对细胞迁移、死亡及关键差异基因表达的影响.总体而言,我们的研究在转录组水平提示了U-104的下游调节机制,并证明了在舌鳞状细胞癌中U-104的抗肿瘤功能依赖于CA9和CA12.此工作拓展了现阶段人们对于U-104抗肿瘤功能的认知,并提供了一类针对舌鳞状细胞癌的潜在治疗方法.
引用
收藏
页码：360 / 368
页数：9
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