Inhibitory effects of captopril on c-myc expression during left ventricular hypertrophy

被引：0

作者：

苏津自

陈达光

吴可贵

陈松苍

胡文养

王向宇

芮红兵

王华军

许昌声

机构：

[1] 福建医科大学附属第一医院心血管内科

[2] 福建省高血压研究所

来源：

ActaPharmacologicaSinica | 1998年 / 06期

关键词：

左心室肥大; 原癌基因类; 原癌基因蛋白c-myc; 血管紧张素Ⅱ; 卡托普利; 近交SHR大鼠; 高血压; RNA印迹; 蛋白质印迹; 免疫组织化学;

D O I：

暂无

中图分类号：

Q-31,R967 [];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

目的：观察卡托普利（Ｃａｐ）对原癌基因ｃｍｙｃ在自发性高血压大鼠（ＳＨＲ）左心室心肌不同细胞类型的表达的影响，探讨Ｃａｐ抑制左心室肥大的分子机制．方法：ＳＨＲ宫内期口服给药（１００ｍｇ·ｋｇ－１·ｄ－１），雄性ＳＨＲ１６周龄时测定收缩压、左室重与体重比．左心室ｃｍｙｃｍＲＮＡ，ＡｎｇⅡ及ｃｍｙｃ癌蛋白表达量分别用ＲＮＡ印迹、免疫组化及蛋白质印迹测定．结果：Ｃａｐ明显降低ＳＨＲ大鼠的收缩压，抑制左心室肥大及ｃｍｙｃ表达，心肌局部ＡｎｇⅡ主要产生于心肌细胞，ｃｍｙｃ则主要源于成纤维细胞．结论：Ｃａｐ通过抑制心肌细胞的ＡｎｇⅡ和成纤维细胞的ｃｍｙｃ表达而逆转左心室肥大

引用

页码：36 / 41

页数：6

共 50 条

[1] Inhibitory effects of captopril on c-myc expression during left ventricular hypertrophy
Su, JZ
Chen, DG
Wu, KG
Chen, SC
Hu, WY
Wang, XY
Rui, HB
Wang, HJ
Xu, CS
ACTA PHARMACOLOGICA SINICA, 1998, 19 (06): : 535 - +
[2] INHIBITION OF LEFT-VENTRICULAR HYPERTROPHY AND EXPRESSION OF PROTOONCOGENES C-MYC OTHER THAN C-FOS IN MYOCARDIUM BY EARLY CAPTOPRIL TREATMENT IN SHR RATS
CHEN, SC
CHEN, DG
BAO, YD
JING, XQ
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[3] C-Myc expression relates to reversal of ventricular function and hypertrophy in patients with aortic valve replacement
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[4] CARDIAC MYOCYTE HYPERTROPHY IS ASSOCIATED WITH C-MYC PROTOONCOGENE EXPRESSION
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[5] REVERSAL OF LEFT-VENTRICULAR HYPERTROPHY WITH CAPTOPRIL
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[6] COMPARISON OF THE EFFECTS OF NITRENDIPINE AND CAPTOPRIL ON THE REGRESSION OF HYPERTENSIVE LEFT VENTRICULAR HYPERTROPHY
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[7] COMPARISON OF THE EFFECTS OF NITRENDIPINE AND CAPTOPRIL ON THE REGRESSION OF HYPERTENSIVE LEFT VENTRICULAR HYPERTROPHY
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[8] EXPRESSION OF C-MYC AND C-FOS IN RAT SKELETAL-MUSCLE - EVIDENCE FOR INCREASED LEVELS OF C-MYC MESSENGER-RNA DURING HYPERTROPHY
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[9] COMPARISON OF THE EFFECTS OF NITRENDIPINE AND CAPTOPRIL ON THE REGRESSION OF HYPERTENSIVE LEFT-VENTRICULAR HYPERTROPHY
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[10] Change of c-myc expression and cardiac hypertrophy in patients with aortic valve replacement
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Ichikawa, H
Ohtake, S
Nishimura, M
Kawaguchi, N
Matsuda, H
ANNALS OF THORACIC SURGERY, 2001, 71 (04): : 1154 - 1159

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