MMP-26和MMP-7在非小细胞肺癌中的表达及其临床意义

被引：6

作者：

张扬 ^{[1
]}

李才 ^{[1
]}

张莲珠 ^{[2
]}

张郑遥 ^{[1
]}

房学迅 ^{[3
]}

邹雅斌 ^{[4
]}

机构：

[1] 吉林大学药学院

[2] 吉林天药科技股份有限公司

[3] 吉林大学分子酶学工程教育部重点实验室

[4] 吉林大学第一临床医院

来源：

现代生物医学进展 | 2009年 / 9卷 / 18期

关键词：

基质金属蛋白酶; 肺肿瘤; 免疫组织化学;

D O I：

10.13241/j.cnki.pmb.2009.18.052

中图分类号：

R734.2 [肺肿瘤];

学科分类号：

摘要：

目的:探讨MMP-26和MMP-7在非小细胞肺癌(NSCLC)中的表达情况及其与其临床病理特征的关系。方法:采用免疫组化的方法对70例NSCLC组织和30例癌旁正常肺组织进行MMP-26和MMP-7表达分析。结果:①肿瘤细胞MMP-26阳性表达率为64.3%;鳞癌、腺癌和大细胞癌组MMP-26表达水平依次降低(P<0.05);随着肿瘤分化程度降低和TNM分期增加MMP-26表达水平下降(P<0.01);②肿瘤细胞MMP-7阳性表达率为57.1%;腺癌MMP-7表达率高于其它组织学类型(P<0.05);MMP-7表达水平与TNM分期有关,且分期越高,表达率越高(P<0.05)。结论:MMP-26表达缺失意味着肿瘤恶性程度高,MMP-7表达增高则提示肿瘤侵袭能力增强。同时检测二者有助于判断NSCLC的恶性程度和预后。

引用

页码：3471 / 3473+3486 +3486

页数：4

共 13 条

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