HIV感染者中HLA-B*5701基因的研究进展

被引:0
|
作者
王颖 [1 ,2 ]
刘静 [2 ]
杨虹 [2 ]
李慧 [2 ]
武玉梅 [2 ]
高雅 [2 ]
杨景元 [2 ]
杲柏呈 [2 ]
郭卫东 [2 ]
李向春 [2 ]
李瑶 [2 ]
机构
[1] 内蒙古医科大学
[2] 内蒙古自治区综合疾病预防控制中心
关键词
艾滋病病毒; HLA-B*5701基因; 阿巴卡韦; 人类白细胞抗原; 免疫反应;
D O I
暂无
中图分类号
R512.91 [获得性免疫缺陷综合征(AIDS艾滋病)];
学科分类号
摘要
人类白细胞抗原(human leukocyte antigen, HLA)基因是主要组织相容性复合体(major histocompatibility complex, MHC)基因家族的成员,HLA-B*5701基因是HLA基因中的一个等位基因。自21世纪初以来,因其与艾滋病抗病毒治疗药物阿巴卡韦的超敏反应密切相关,同时有益于延缓HIV感染者的疾病进展,而得到了广泛关注,国内外多位学者对此基因进行了研究。本文综述了HLA-B*5701等位基因与阿巴卡韦超敏反应的相关性、药前筛查阿巴卡韦超敏反应的应用和此筛查在不同人群中的适用性,并对此等位基因可延缓HIV疾病进展的相关研究做了简要介绍。
引用
收藏
页码:348 / 351
页数:4
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