Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress

被引：0

作者：

Jianbo Zhao ^{[1
]}

Shiqiang Fang ^{[1
]}

Yajiang Yuan ^{[1
]}

Zhanpeng Guo ^{[1
]}

Jinhao Zeng ^{[1
]}

Yue Guo ^{[1
]}

Peifu Tang ^{[2
]}

Xifan Mei ^{[1
]}

机构：

[1] Vertebral Column Ward,Department of Orthopedics,First Affiliated Hospital of Liaoning Medical University

[2] Department of Orthopedics,General Hospital of People’s Liberation Army

来源：

Neural Regeneration Research | 2014年 / 9卷 / 14期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

nerve regeneration; spinal cord injury; nerve cells; green tea polyphenols; spinal cord neurons; oxidative stress; apoptosis; malondialdehyde; superoxide dismutase; rats; NSFC grant; neural regeneration;

D O I：

暂无

中图分类号：

R651.2 [脊髓];

学科分类号：

1002 ; 100210 ;

摘要：

Green tea polyphenols are strong antioxidants and can reduce free radical damage. To investigate their neuroprotective potential, we induced oxidative damage in spinal cord neurons using hydrogen peroxide, and applied different concentrations(50–200 μg/mL) of green tea polyphenol to the cell medium for 24 hours. Measurements of superoxide dismutase activity, malondialdehyde content, and expression of apoptosis-related genes and proteins revealed that green tea polyphenol effectively alleviated oxidative stress. Our results indicate that green tea polyphenols play a protective role in spinal cord neurons under oxidative stress.

引用

页码：1379 / 1385

页数：7

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