POLYMORPHISMS OF APOLIPOPROTEIN B GENE IN RELATION TO CORONARY HEART DISEASE IN CHINESE HAN NATIONALITY

Two polymorphic sites of apolipoprotein B (apoB) gene,Xbal and EcoRl, were examined in 80 patients with docu-mented coronary heart disease (CHD) and 60 healthy individuals selected from a population of Chinese Han nationality.Allele frequencies at these sites were compared between the pa-tients and controls and their impact on lipid metabolism was also investigated. The frequency of X+ allele (presence of Xbalcutting site) in CHD patients was 0.10, which was significantlyhigher than 0.01 in controls (p〈0.001). The same trend wasdetected for frequency of E-allele (lack of EcoRl cutting site)when it was compared between CHD patients and controls(0.11 vs 0.05), the difference was not statistically significant