This paper includes three parts: (1) The main characteristics of knowledge economics in new era; (2) Innovation management is an inevitable trend; (3) Corporate culture lead literary excellence. With the advance of science technique and development of productive force , huma nity entered on knowledge economics era.It is a new social economic pattern that occupy and coordinate intellectual resources and causes some essential changes of produce method. Investment pattern, industrial construction, through idea and social organization. Since these changes, the traditional management method don’t meet the need of new times and make some trouble to the enterprise, and then innovation managemen t yield and give good function for knowledge economic era. Adhere to some scienc e create regulation; Accord with the times requirement; Raise output rate and pr omote society productivity; Need a process of time and guard against impetuosity . The application of innovation management to enterprise produce marked success in which corporate culture leads literary excellence.