Contribution of interleukin-1beta in neuropathic pain

被引:0
|
作者
GUO Wei [1 ]
机构
[1] Department of Neural and Pain Sciences, Dental School &Program in Neuroscience, University of Maryland
关键词
白细胞介素1β; 神经痛; 细胞因子类; 神经胶质;
D O I
暂无
中图分类号
R741 [神经病学];
学科分类号
1002 ;
摘要
炎性因子白细胞介素1β(IL-1β)参与神经病理性疼痛的中枢和周围敏化过程,此为其特征性病理变化。IL-1β是介导中枢神经系统胶质细胞与神经元相互作用的重要炎性因子,其活化受到其他炎性因子的调控,如趋化细胞因子配体2(CCL2)和基质金属蛋白酶2、9(MMP 2、9)等。本文简要概述IL-1β在中枢性和周围性神经病理性疼痛中的主要作用机制。
引用
收藏
页码:744 / 746
页数:3
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