Effects of age on immune function in broiler chickens

Background: There are many diseases in poultry, many of which are caused by poor immune function. It is not clear how cytokines and various immune cell functions change with age in modern broilers. The purpose of this study was to explore the patterns of development of the immunity of the broiler chickens in cage.Results: The results showed that there were 3 development patterns of immunity in the broiler chickens. The first pattern was Down-Up. Cytokines and some immune indicators first decreased and then increased, and the lowest levels of immunity basically occurred from d 6 to 13. The second pattern was Up-Down, and from d 30 to 34, the highest levels of non-specific cellular immunity components, such as the peripheral blood mononuclear macrophage ratio, specific cellular immunity components, such as the peripheral blood helper T(Th) cell ratio and T cell and B cell proliferation activity, and mucosal immunity components, such as the ileal CD4, TGF-β1 and Ig A m RNA levels, were observed. The third pattern was Up-Up, and the levels of the non-specific cellular immunity components, such as the serum nitric oxide(NO), C3 and C4 levels, the specific cellular immunity components,such as the spleen index, peripheral blood IL-2, IFN-γ/IL-4, cytotoxic T(Tc) cell ratio, and splenic NF-κB m RNA levels,the humoral immunity components, such as the serum Ig G level, the mucosal immunity components, such as the ileal MHC-II, CD3 d, TCRβ subunit, TCRζ subunit, IFN-γ, p Ig R m RNA and ileal mucosa s Ig A levels, were continuing to increase from d 1 to 34.Conclusions: It could be concluded that the immune system and its function have not developed well in the broiler chickens d 6 to 13 and that the immune system does not mature until d 30 to 34 in the broiler chickens in cages. It is necessary to enhance the immune function of the broiler chickens through nutritional measures from d1 to 30.