细胞周期检测点激酶CHK1、CHK2与放射敏感性

[1] Wang X,Khadpe J,Hu B,et al.An overactivated ATR/CHK1pathway is responsible for the prolonged G2accu-mulation in irradiated AT cells. Journal of Biological Chemistry . 2003

[2] Goudelock DM,Jiang K,Pereira E,et al.Regulatory in-teractions between the checkpoint kinase Chk1and the proteins of the DNA-dependent protein kinase complex. Journal of Biological Chemistry . 2003

[3] Shao RG,Cao CX,Pommier Y.Abrogation of Chk1-medi-ated S/G2checkpoint by UCN-01enhances ara-C-induced cytotoxicity in human colon cancer cells. Acta Pharmacological Sinica . 2004

[4] Craig A,Scott M,Burch L,et al.Allosteric effects mediate CHK2phosphorylation of the p53transactivation domain. EMBO Reports . 2003

[5] Zhou XY,Wang X,Hu B,et al.An ATM-independent s-phase checkpoint response involves CHK1pathway. Cancer Research . 2002

[6] Sorensen CS,Syljuasen RG,Lukas J,et al.ATR,Claspin and the Rad9-Rad1-Hus1complex regulate Chk1and Cdc25A in the absence of DNA damage. Cell Cycle . 2004

[7] Li J,Stern DF.Regulation of Chk2by DNA-dependent protein kinase. Journal of Biological Chemistry . 2005

[8] Sorensen CS,Syljuasen RG,Falck J,et al.Chk1regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated prote-olysis of Cdc25A. Cancer Cell . 2003

[9] Tominaga K,Morisaki H,Kaneko Y,et al.Role of human Cds1(Chk2)kinase in DNA damage checkpoint and its regulation by p53. Journal of Biological Chemistry . 1999

[10] Chehab NH,Malikzay A,Appel M,et al.Chk2/hCds1functions as a DNA damage checkpoint in G(1)by stabi-lizing p53. Genes and Development . 2000

[1] Wang X,Khadpe J,Hu B,et al.An overactivated ATR/CHK1pathway is responsible for the prolonged G2accu-mulation in irradiated AT cells. Journal of Biological Chemistry . 2003

[2] Goudelock DM,Jiang K,Pereira E,et al.Regulatory in-teractions between the checkpoint kinase Chk1and the proteins of the DNA-dependent protein kinase complex. Journal of Biological Chemistry . 2003

[3] Shao RG,Cao CX,Pommier Y.Abrogation of Chk1-medi-ated S/G2checkpoint by UCN-01enhances ara-C-induced cytotoxicity in human colon cancer cells. Acta Pharmacological Sinica . 2004

[4] Craig A,Scott M,Burch L,et al.Allosteric effects mediate CHK2phosphorylation of the p53transactivation domain. EMBO Reports . 2003

[5] Zhou XY,Wang X,Hu B,et al.An ATM-independent s-phase checkpoint response involves CHK1pathway. Cancer Research . 2002

[6] Sorensen CS,Syljuasen RG,Lukas J,et al.ATR,Claspin and the Rad9-Rad1-Hus1complex regulate Chk1and Cdc25A in the absence of DNA damage. Cell Cycle . 2004

[7] Li J,Stern DF.Regulation of Chk2by DNA-dependent protein kinase. Journal of Biological Chemistry . 2005

[8] Sorensen CS,Syljuasen RG,Falck J,et al.Chk1regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated prote-olysis of Cdc25A. Cancer Cell . 2003

[9] Tominaga K,Morisaki H,Kaneko Y,et al.Role of human Cds1(Chk2)kinase in DNA damage checkpoint and its regulation by p53. Journal of Biological Chemistry . 1999

[10] Chehab NH,Malikzay A,Appel M,et al.Chk2/hCds1functions as a DNA damage checkpoint in G(1)by stabi-lizing p53. Genes and Development . 2000