rhBMP-2与脊柱融合

被引：3

作者：

陈伟富

洪正华

陈海啸

机构：

[1] 温州医学院附属台州医院骨科

来源：

实用医学杂志 | 2007年 / 21期

关键词：

脊柱融合; 自体骨; 腰椎; 融合率; 后外侧融合; 明胶海绵; rhBMP-2; 椎间融合器;

D O I：

暂无

中图分类号：

R687.3 [骨骼手术];

学科分类号：

摘要：

<正>1965年,Urist[1]首次将脱钙骨基质植入动物非骨骼部位,成功地诱导了异位成骨,后来被命名为骨形成蛋白(BMP)。此后,BMP被广泛深入的研究,以修复各种骨创伤缺损和退行性疾病。直到1988年[2],随着分子克隆技术的发展及众多关于此蛋白研究,已证明其属于β转化生长因子超家族成员。目前,已经研究出BMP的分子遗传机制,并发现15种以上不同人重组BMP,其中以人重组BMP-2(rhBMP-2)诱骨活性最强,与其他rhBMP有协同作用,近年来rhBMP-2

引用

页码：3453 / 3455

页数：3

共 12 条

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