Clinical Toxicology, Pharmacology and Therapeutic Study

P2-1 Effect of Bupleuri radix(BR) extracts on the toxicity of 5-fluorouracil in normal human lymphocytes and hepatoma cell lines(HepG2/Hep3B)SJ KANG, HD WOO, JY CHOI, YJ LEE, HW CHUNG(School of Public Health, Seoul National University 28 Yonkon-dong, Chongro-ku, 110-460, Seoul, KoreaAbstract:5-Flourouracil(5-FU) is one of well known anti-cancer drugs, but its toxicity in normal lymphocytes remains a major problem in chemotherapy. The eastern traditional drug, Bupleuri radix(BR), has been used for the treatment of liver diseases and contains series of triterpene saponins. BR is known to exert its antioxidative activity by scavenging reactive oxidative species.