Plk1与人类肿瘤生成

被引:1
|
作者
孙威
陈爱山
闫兆鹏
曹献馗
刘宝林
机构
[1] 中国医科大学附属盛京医院结直肠肛门病外科
关键词
Plk1; 肿瘤生成; 抑癌基因; 肿瘤治疗;
D O I
暂无
中图分类号
R730.2 [肿瘤病理学、病因学];
学科分类号
摘要
人类肿瘤生成过程主要表现为细胞生长的失调控,而Plk1是细胞周期进行有丝分裂、胞质分裂及DNA损伤反应的关键调节因子。通过对Plk1在中心体周期中作用的认识,推测在多种癌症中可检测到Plk1表达的失控,且与人类肿瘤生成有关。研究发现,Plk1在人类多种肿瘤中存在高表达,且其高表达与肿瘤患者的细胞增殖及预后相关。应用不同方法下调Plk1的表达水平在体外细胞培养及活体动物实验中均被证实有抑制肿瘤细胞增殖及促进其凋亡的作用,但对正常细胞却无明显杀伤。因此,靶向作用于Plk1的治疗可能成为人类肿瘤治疗的新的很有潜力的方法。
引用
收藏
页码:1300 / 1303
页数:4
相关论文
共 11 条
  • [1] Inhibitory effect of Polo-like kinase 1 depletion on mitosis and apoptosis of gastric cancer cells[J]. Xue-Hua Chen Ying Qu Xiao-Qing Zhang Qu Cai Bing-Ya Liu Zheng-Gang Zhu,Department of Surgery,Shanghai Institute of Digestive Surgery,Ruijin Hospital,Medical School of Shanghai Jiao Tong University,Shanghai 200025,China Bin Lan,Department of Surgical Oncology,the First Affiliated Hospital,Fujian Medical University,Fuzhou 350005,Fujian Province,China. World Journal of Gastroenterology. 2
  • [2] p53-dependent repression of polo-like kinase-1 (PLK1)
    McKenzie, Lynsey
    King, Sharon
    Marcar, Lynnette
    Nicol, Sam
    Dias, Sylvia S.
    Schumm, Katie
    Robertson, Pamela
    Bourdon, Jean-Christophe
    Perkins, Neil
    Fuller-Pace, Frances
    Meek, David W.
    [J]. CELL CYCLE, 2010, 9 (20) : 4200 - 4212
  • [3] Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research and Treatment of Cancer (EORTC) Network Of Core Institutes (NOCI)[J] . European Journal of Cancer . 2010 (12)
  • [4] Polo-Like Kinase 1 as Predictive Marker and Therapeutic Target for Radiotherapy in Rectal Cancer
    Roedel, Franz
    Keppner, Sarah
    Capalbo, Gianni
    Bashary, Robina
    Kaufmann, Manfred
    Roedel, Claus
    Strebhardt, Klaus
    Spaenkuch, Birgit
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2010, 177 (02): : 918 - 929
  • [5] Uptake of plasmid-loaded nanoparticles in breast cancer cells and effect on Plk1 expression
    Steinhauser, Isabel
    Langer, Klaus
    Strebhardt, Klaus
    Spaenkuch, Birgit
    [J]. JOURNAL OF DRUG TARGETING, 2009, 17 (08) : 627 - 637
  • [6] Effect of antisense RNA targeting Polo-like kinase 1 on cell growth in A549 lung cancer cells[J] . Qiong Zhou,Yuan Su,Ming Bai. Journal of Huazhong University of Science and Technology[Medical Sciences] . 2008 (1)
  • [7] BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo[J] . Current Biology . 2007 (4)
  • [8] ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent[J] . Kiranmai Gumireddy,M.V. Ramana Reddy,Stephen C. Cosenza,R. Boomi Nathan,Stacey J. Baker,Nabisa Papathi,Jiandong Jiang,James Holland,E. Premkumar Reddy. Cancer Cell . 2005 (3)
  • [9] Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells .2 Liu X,Erikson R L. Proc Nail Acad Sci USA . 2003
  • [10] Centrosomes as command centres for cellular control .2 Doxsey,S.J. Nat Cell Biol . 2001