Unique GGT→GTT mutation at K-ras codon 12 in six human pancreatic cancer cell lines from Chinese patients

被引：0

作者：

魏拴增

刘彤华

刘鸿瑞

高洁

机构：

[1] Department of Pathology

[2] Peking Union Medical College Hospital

[3] Chinese Academy of Medical Science

[4] Chinese Academy of Medical Science Beijing 100730

[5] China

来源：

中华医学杂志(英文版) | 2003年 / 10期

关键词：

pancreatic cancer · K-ras · mutation;

D O I：

暂无

中图分类号：

R735.9 [胰腺肿瘤];

学科分类号：

100214 ;

摘要：

Objective To investigate the K-ras mutation pattern in six pancreatic cancer cell lines from Chinese patients. Methods All six cell lines were analyzed for mutations in exon 1 of the K-ras gene by polymerase chain reaction (PCR) and direct sequencing.Results All 6 pancreatic cancer cell lines had GGT→GTT mutations at K-ras codon 12 but no mutations at codon 13.Conclusion The unique GGT→GTT mutation at codon 12 plays a potential role in the carcinogenesis of pancreatic cancers in Chinese.

引用

页码：145 / 147

页数：3

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