血清6-keto-PGE1α水平对监测盘源性腰痛的临床价值<spanid="corr-video"class="type"style="display:none">附视频</span>

被引：5

作者：

沈影超

沈忆新

机构：

[1] 南京中医药大学附属常熟市中医院

来源：

颈腰痛杂志 | 2008年 / 03期

关键词：

盘源性腰痛; 渗透性; 前列腺素E2; 6-keto-PGE1α;

D O I：

暂无

中图分类号：

R681.5 [脊柱及背疾病];

学科分类号：

摘要：

目的对血清前列腺素E(2PGE2)代谢产物6-keto-PGE1α与退变椎间盘渗透性改变的相关性进行研究,探讨PGE2作为反映盘源性腰痛的特异性炎症指标的可能性。方法①收集20例盘源性腰痛分为治疗前和治疗后两组,分别测定两组血清标本前列腺素E2水平。②采用同期健康献血者10名,作为健康对照组。结果A组(盘源性腰痛患者治疗前)53.8470±13.763pg/ml,B组(盘源性腰痛患者治疗后)46.1025±5.516pg/ml,A组明显高于B组及C组,差异具有显著性(P<0.05)。对A、B两组资料进行配对t检验发现t=2.875,经双尾检验P<0.05,盘源性腰痛患者治疗前后差异具有显著性意义。结论①前列腺素E2与盘源性腰痛炎症机制密切相关。②监测血清6-keto-PGE1α能很好的反映出椎间盘内的渗透性变化和盘内炎症水平。

引用

页码：202 / 205

页数：4

共 7 条

[1] 骨骼系统基本生物力学[M]. 天津科学技术出版社 , (美)弗兰克尔(Frankel, 1986
[2] Nutrition of the intervertebral disc
Urban, JPG
Smith, S
Fairbank, JCT
[J]. SPINE, 2004, 29 (23) : 2700 - 2709
[3] Higher levels of antibodies against the psoriasis-associated antigen Pso p27 in cerebrospinal fluid from patients with low back pain and sciatica
Zwart, JA
Iversen, OJ
Sand, T
Dale, LG
Unsgård, G
[J]. SPINE, 1999, 24 (04) : 373 - 377
[4] Toward a Biochemical Understanding of Human Intervertebral Disc Degeneration and Herniation: Contributions of Nitric Oxide, Interleukins, Prostaglandin E2, and Matrix Metalloproteinases[J] . James D. Kang,Maja Stefanovic-Racic,Lori A. McIntyre,Helga I. Georgescu,Christopher H. Evans.Spine . 1997 (10)
[5] Herniated Lumbar Intervertebral Discs Spontaneously Produce Matrix Metalloproteinases, Nitric Oxide, Interleukin-6, and Prostaglandin E2[J] . James D. Kang,Helga I. Georgescu,Lori McIntyre-Larkin,Maja Stefanovic-Racic,William F. Donaldson,Christopher H. Evans.Spine . 1996 (3)
[6] STRAIGHT LEG RAISING TEST AND LUMBAR CEREBROSPINAL-FLUID LEVELS OF VASOACTIVE INTESTINAL POLYPEPTIDE AND SOMATOSTATIN IN PATIENTS WITH LOW-BACK-PAIN
GRONBLAD, M
LUKINMAA, A
JOLKKONEN, J
SCHUGK, P
SEITSALO, S
KORKALA, O
ERVASTI, H
[J]. SPINE, 1994, 19 (13) : 1462 - 1466
[7] Human Intradiscal Levels with Cefazolin[J] . James B. Boscardin,Julius C. Ringus,Deborah J. Feingold,Susan C. Ruda.Spine . 1992 (6 Su)

← 1 →