Effects of adenosine triphosphate concentration on motor force regulation during skeletal muscle contraction

被引：0

作者：

J.Wei ^{[1
]}

C.Dong ^{[1
]}

B.Chen ^{[1
]}

机构：

[1] Department of Engineering Mechanics,Zhejiang University

来源：

Acta Mechanica Sinica | 2017年 / 33卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Motor force regulation; ATP; Muscle contraction; Myosin;

D O I：

暂无

中图分类号：

R318.01 [生物力学];

学科分类号：

0831 ;

摘要：

We employ a mechanical model of sarcomere to quantitatively investigate how adenosine triphosphate(ATP)concentration affects motor force regulation during skeletal muscle contraction. Our simulation indicates that there can be negative cross-bridges resisting contraction within the sarcomere and higher ATP concentration would decrease the resistance force from negative cross-bridges by promoting their timely detachment. It is revealed that the motor force is well regulated only when ATP concentration is above a certain level. These predictions may provide insights into the role of ATP in regulating coordination among multiple motors.

引用

页码：243 / 249

页数：7

共 50 条

[1] Effects of adenosine triphosphate concentration on motor force regulation during skeletal muscle contraction
Wei, J.
Dong, C.
Chen, B.
ACTA MECHANICA SINICA, 2017, 33 (02) : 243 - 249
[2] Effects of adenosine triphosphate concentration on motor force regulation during skeletal muscle contraction
J. Wei
C. Dong
B. Chen
Acta Mechanica Sinica, 2017, 33 : 243 - 249
[3] Regulating motor force in skeletal muscle contraction
Chen, B.
Gao, H.
MOLECULAR BIOLOGY OF THE CELL, 2011, 22
[4] Motor Force Homeostasis in Skeletal Muscle Contraction
Chen, Bin
Gao, Huajian
BIOPHYSICAL JOURNAL, 2011, 101 (02) : 396 - 403
[5] Catch-slip bonds can be dispensable for motor force regulation during skeletal muscle contraction
Dong, Chenling
Chen, Bin
PHYSICAL REVIEW E, 2015, 92 (01):
[6] How is the motor force regulated in skeletal muscle contraction?
Chen, B.
MOLECULAR BIOLOGY OF THE CELL, 2014, 25
[7] BREAKDOWN OF ADENOSINE TRIPHOSPHATE DURING A SINGLE CONTRACTION OF WORKING MUSCLE
CAIN, DF
DAVIES, RE
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1962, 8 (05) : 361 - &
[8] Self-Regulation of Motor Force Through Chemomechanical Coupling in Skeletal Muscle Contraction
Chen, Bin
JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME, 2013, 80 (05):
[9] Self-regulation of motor force through chemomechanical coupling in skeletal muscle contraction
Chen, B. (chenb6@zju.edu.cn), 1600, American Society of Mechanical Engineers (ASME), United States (80):
[10] The effect of muscle contraction on the regulation of adenosine formation in rat skeletal muscle cells
Hellsten, Y
JOURNAL OF PHYSIOLOGY-LONDON, 1999, 518 (03): : 761 - 768

← 1 2 3 4 5 →