Novel Bone-targeted Agents for Treatment of Osteoporosis

被引：0
|
作者：
Jun Bo WANG
机构：
来源：
Chinese Chemical Letters | 2005年 / 07期
关键词：
Osteoporosis; bone-targeted; raloxifene; bisphosphonate;
D O I：
暂无
中图分类号：
R58 [内分泌腺疾病及代谢病];
学科分类号：
1002 ; 100201 ;
摘要：
The novel bone-targeted agents were designed and synthesized by the combination of raloxifene and bisphosphonates. The anti-osteoporosis effect was evaluated by bone mineral density (BMD) obtained from OVX mice in vivo. The results indicated that the compound 8, 9 not only prevented ovariectomy induced loss of bone but also enhanced BMD to 0.87% and 19.67% compared to Sham, respectively.
引用
收藏
页码：859 / 862
页数：4
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