老年不稳定型心绞痛患者P2Y12受体基因多态性对氯吡格雷抑制血小板聚集率的影响

被引：4
|
作者：
谭艳武 [1 ]
罗伟陵 [1 ]
赵迪诚 [2 ]
机构：
[1] 湖南师范大学附属湘东医院心内科
[2] 中南大学医学遗传学实验室
来源：
湖南师范大学学报(医学版) | 2014年 / 11卷 / 02期
关键词：
冠心病; 不稳定型心绞痛; 氯吡格雷P2Y12受体; 基因多态性; 血小板聚集率;
D O I：
暂无
中图分类号：
R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];
学科分类号：
摘要：
目的:探讨老年不稳定心绞痛患者P2Y12受体基因多态性对氯吡格雷抑制血小板聚集率的影响。方法:筛选255名老年不稳定型心绞痛患者,检测P2Y12外显子C34T和G52T多态性。测定服氯吡格雷前及服该药300mg后6 h血小板聚集率。结果:P2Y12外显子C34T、G52T的位点基因突变频率分别为16.01%和25.00%,其频率分布符合Hardy-Weinberg平衡。在5μmol/LADP诱导血小板聚集实验中,34T突变型组血小板聚集率降低的程度显著大于34C野生型组;52T突变型组血小板聚集率降低的程度显著小于52G野生型组。结论:老年不稳定心绞痛患者存在P2Y12受体基因多态性,P2Y12受体外显子C34T突变增强氯吡格雷抑制血小板聚集的作用,G52T突变减弱氯吡格雷抑制血小板聚集作用。
引用
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页码：49 / 51
页数：3
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