Risk factors influencing mortality of patients with severe acute pancreatitis within 24 hours after admission

OBJECTIVE: To study the risk factors for death of patients with severe acute pancreatitis (SAP) within24 hours after admission.METHODS: Clinical and laboratory data of 74 patients with SAP were analyzed retrospectively. The 27possible risk factors for death within 24 hours after admission were investigated using logistic regression(SPSS software package 10.0), and the equation of logistic regression was set up.RESULTS: Among the 27 possible risk factors, arterial pH, APACHE Ⅱ scores, early shock, multipleorgan failure were associated with mortality. Single logistic regression analysis of the 27 parameters showedthat early shock, pleural effusion, arterial pH, complications and APACHE Ⅱ scores were associated withdeath of SAP patients, but using multiple logistic regression analysis showed that only acidosis (pH<7.35) was associated with death.CONCLUSION: To maintain the function of organs and correct dysequilibrium of water-electrolyte andacid-base in early treatment of SAP is essential to lower the mortality.