eIF-5A与hypusine

被引：1

作者：

靳宝锋

何昆

张学敏

机构：

[1] 军事医学科学院基础医学研究所

来源：

军事医学科学院院刊 | 2003年 / 06期

关键词：

eIF-5A; hypusine; 蛋白质合成; 细胞凋亡;

D O I：

暂无

中图分类号：

R341 [];

学科分类号：

摘要：

翻译起始因子eIF5A在真核细胞内普遍存在 ,是目前为止惟一发现含独特氨基酸hypusine残基的蛋白。hypusine是eIF5A前体的特定赖氨酸残基（第 5 0位）经亚精胺依赖性的翻译后修饰形成的 ,每一成熟的eIF5A仅含一个hypusine残基 ,eIF5A的hypusine修饰是其发挥功能、细胞存活和增殖所必需的。本文对eIF5A的研究历史、现状和hypusine功能的近期进展进行了概述 ,并进一步分析了eIF5A的可能功能及hypusine修饰过程作为药物靶标诱导细胞凋亡的应用前景。

引用

页码：463 / 466

页数：4

共 24 条

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