Clostridium difficile causing acute renal failure: Case presentation and review

被引:0
|
作者
Jasmin Arrich
Gottfried H.Sodeck
Gürkan Seng(o|¨)lge
Christoforos Konnaris
Marcus Müllner
Anton N.Laggner
Hans Domanovits
机构
[1] A-1090
[2] Austria
[3] Department of Emergency Medicine
[4] Department of Emergency Medicine Medical University Vienna
[5] Department of Internal Medicine Ⅳ
[6] Department of Medicine Ⅲ
[7] Division of Nephrology and Dialysis
[8] Division of Occupational Medicine
[9] General Hospital
[10] Medical University Vienna General Hospital W(a|¨)hringer Gürtel 18-20
[11] W(a|¨)hringer Gürtel 18-20
关键词
Acute renal failure; Clostridium difficile; Diarrhea;
D O I
暂无
中图分类号
R692.5 [肾功能衰竭];
学科分类号
1002 ; 100210 ;
摘要
AIM: Clostridium difficile infection is primarily a nosocomial infection but asymptomatic carriers of Clostridium difficile can be found in up to 5% of the general population. Ampicillin, cephalosporins and clindamycin are the antibiotics that are most frequently associated with Clostridium difficile-associated diarrhea or colitis. Little is known about acute renal failure as a consequence of Clostridium difficile-associated diarrhea. METHODS: In this case report, we describe the course of Clostridium difficile-associated diarrhea in an 82-year-old patient developing acute renal failure. Stopping the offending agent and symptomatic therapy brought a rapid improvement of diarrhea and acute renal failure, full recovery was gained 18 d after admission. In a systematic review we looked for links between the two conditions. RESULTS: The link between Clostridium difficile-assoaated diarrhea and acute renal failure in our patient was most likely volume depletion. However, in experimental studies a direct influence of Clostridium difficile toxins on renal duct cells could be shown. CONCLUSION: Rapid diagnosis, nonspecific supportive treatment and specific antibiotic treatment, especially in the elderly, may lower excess mortality Clostridium difficile-associated diarrhea and renal failure being possible complications.
引用
收藏
页码:1245 / 1247
页数:3
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