Synthesis,Crystal Structure and Antitumor Activity of(E)-N-(4-Fluorobenzylidene)-3-(methylthio)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine

被引：0

作者：

林伟源 ^{[1
]}

杨芳 ^{[1
]}

段安娜 ^{[1
]}

游文玮 ^{[1
]}

赵培亮 ^{[1
]}

机构：

[1] Guangdong Provincial Key Laboratory of New Drug Screening,School of Pharmaceutical Science,Southern Medical University

来源：

Chinese Journal of Structural Chemistry | 2018年 / 37卷 / 10期

基金：

中国国家自然科学基金;

关键词：

(E)-N-(4-fluorobenzylidene)-3-(methylthio)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine; synthesis; crystal structure; antitumor activity;

D O I：

10.14102/j.cnki.0254-5861.2011-1967

中图分类号：

TQ460.1 [基础理论];

学科分类号：

1007 ;

摘要：

The crystal structure of the title compound(E)-N-(4-fluorobenzylidene)-3-(methylthio)-5-(3,4,5-trimethoxyphenyl)-4 H-1,2,4-triazol-4-amine(CHFNOS,Mr = 402.44) was synthesized,and its structure was characterized by 1 H-NMR,13 C-NMR,ESI-MS and single-crystal X-ray diffraction.The crystal belongs to the triclinic system,space group P1 with a = 9.228(13),b = 10.364(14),c = 10.641(14) ?,α = 85.323(3),β = 75.172(2),γ = 80.903(3)°,μ = 0.20 mm,M= 402.44,V = 970.64(10) ?~3,Z = 2,D= 1.377 g/cm~3,F(000) = 420,R = 0.0484 and wR = 0.1474 for 3181 observed reflections with I > 2σ(I).In addition,the preliminary bioassay indicated that the title compound 5 exhibits better inhibitory activity against Hela than 5-fluorouracil.

引用

页码：1557 / 1562

页数：6

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