Interaction among Rb/p16, Rb/E2F1 and HDAC1 Proteins in Gallbladder Carcinoma

被引：0
|
作者：
王欣 [1 ]
黄凯 [2 ]
徐立宁 [3 ]
机构：
[1] Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
[2] Huangshi Ninth Hospital
[3] Department of Hepatobiliary Surgery, General Hospital of PLA
来源：
Current Medical Science | 2009年 / 29卷 / 06期
关键词：
Rb; p16; E2F1; HDAC1; gallbladder carcinoma; cell line; protein interaction;
D O I：
暂无
中图分类号：
R735.8 [胆囊、胆道肿瘤];
学科分类号：
100214 ;
摘要：
The mechanism and interaction among Rb/p16, Rb/E2F1 and HDAC1 proteins in gallbladder carcinoma were investigated. By using the immunoprecipitation method, the interactions among Rb, p16, E2F1, HDAC1 proteins in gallbladder carcinoma cell line (Mz-ChA-1) were studied. It was found that there were Rb and E2F1 proteins in the precipitates with anti-HDAC1, and there were HDAC1 and E2F1 proteins in the precipitate with anti-Rb. It was concluded that there are specific interactions among Rb, HDAC1 and E2F1 proteins in gallbladder carcinoma, indicating the existence of the direct Rb/E2F1/HDAC1 signal transduction pathway. There is no direct relationship between p16 proteins with Rb, HDAC1, and E2F1 proteins.
引用
收藏
页码：729 / 731
页数：3
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