EXPRESSION OF BONE MORPHOGENETIC PROTEIN-1 IN FETAL HUMAN CARTILAGE AND BONE DURING ENDOCHONDRAL OSSIFICATION

被引：0
|
作者：
滕华建
曲绵域
田得祥
林共周
党喜同
机构：
来源：
Chinese Medical Sciences Journal | 1998年 / 03期
基金：
中国国家自然科学基金;
关键词：
BMP-1; cartilage; bone;
D O I：
暂无
中图分类号：
R681.3 [软骨疾病];
学科分类号：
1002 ; 100210 ;
摘要：
The expression of mRNA for bone morphogenetic protein-1 (BMP-1) was investigated in fetal human cartilage and bone during the developing endochondral ossification by using in situ hybridization. BMP-1 mRNA was localized in the hypertrophic chondrocytes, the cells of perichondrium, osteoblasts and marrow cells. The results suggest that BMP-1 may involve in cartilage and bone formation, and in regulation of calcification of growth plate.As a comparative study, the expression of TGF-β1 protein was investigated in cartilage and bone using immunohistochemical staining, correlated expression of TGF-β1 and BMP-1 was found. The results suggest that BMP-1 and TGF-β1 act synergistically to influence endochrondral ossification.
引用
收藏
页码：129 / 133
页数：5
相关论文
共 50 条
  • [1] Bone morphogenetic protein (BMP)-3 mRNA expression in endochondral ossification.
    Fujimoto, T
    Kitazawa, R
    Mori, H
    Mizuno, K
    Maeda, S
    Kitazawa, S
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 : S309 - S309
  • [2] Bone morphogenetic protein-1 expression during rat tibia bone formation.
    Manduca, P
    Zanotti, S
    Volta, C
    Galmozzi, F
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 : S222 - S222
  • [3] Bone morphogenetic protein 2 stimulates endochondral ossification by regulating periosteal cell fate during bone repair
    Yu, Yan Yiu
    Lieu, Shirley
    Lu, Chuanyong
    Colnot, Celine
    [J]. BONE, 2010, 47 (01) : 65 - 73
  • [4] COORDINATE EXPRESSION OF OSTEOGENIC PROTEIN-1 (BONE MORPHOGENETIC PROTEIN-7) AND BONE MORPHOGENETIC PROTEIN-3 (OSTEOGENIN) DURING MOUSE AND HUMAN-DEVELOPMENT
    HELDER, M
    OZKAYNAK, E
    LUYTEN, FP
    SAMPATH, TK
    OPPERMANN, H
    VUKICEVIC, S
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 1993, 8 : S316 - S316
  • [5] Bone morphogenetic protein 2/7 promotes repair of bone defect via induction of endochondral ossification
    Wu, Jianjun
    Zheng, Changkun
    Liang, Guiqing
    [J]. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2021, 20 (01) : 35 - 40
  • [6] Transforming growth factor-β1:: Induction of bone morphogenetic protein genes expression during endochondral bone formation in the baboon, and synergistic interaction with osteogenic protein-1 (BMP-7)
    Duneas, N
    Crooks, J
    Ripamonti, U
    [J]. GROWTH FACTORS, 1998, 15 (04) : 259 - +
  • [7] Bone morphogenetic protein signaling in chondrocyte proliferation and hypertrophy during endochondral bone formation
    Iwai, T
    Horiki, M
    Murai, J
    Yoshikawa, H
    Tsumaki, N
    [J]. BONE, 2005, 36 : S174 - S175
  • [8] Bone morphogenetic protein-1 processes probiglycan
    Scott, IC
    Imamura, Y
    Pappano, WN
    Troedel, JM
    Recklies, AD
    Roughley, PJ
    Greenspan, DS
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (39) : 30504 - 30511
  • [9] EXPRESSION PATTERN OF OSTEOGENIC PROTEIN-1 (BONE MORPHOGENETIC PROTEIN-7) IN HUMAN AND MOUSE DEVELOPMENT
    HELDER, MN
    OZKAYNAK, E
    SAMPATH, KT
    LUYTEN, FP
    LATIN, V
    OPPERMANN, H
    VUKICEVIC, S
    [J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1995, 43 (10) : 1035 - 1044
  • [10] Endochondral ossification: How cartilage is converted into bone in the developing skeleton
    Mackie, E. J.
    Ahmed, Y. A.
    Tatarczuch, L.
    Chen, K. -S.
    Mirams, M.
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2008, 40 (01): : 46 - 62
12345