Retroviral mediated human β-globin gene transfer and expression in vitro

被引：0

作者：

Depei Liu

机构：

来源：

中国实验血液学杂志 | 1997年 / 03期

关键词：

gene; Retroviral mediated human; globin gene transfer and expression in vitro;

D O I：

暂无

中图分类号：

R346 [];

学科分类号：

1001 ;

摘要：

Retroviral mediated gene transfer of humanglobin gene into hematopoietic stem cells is apromising approach for thalassemia gene therapy.Major problem of the transferred globin gene was lowlevel expression of the gene with its proximal cis-acting sequence. The locus control region (LCR) ofthe human β-globin gene cluster consists of four majorDNase I hypersensitive sites (HS). When linked to

引用

页码：286 / 286

页数：1