Clinical outcomes of gastrointestinal stromal tumor in southern Thailand

被引:0
|
作者
Kittima Pornsuksiri [1 ]
Siripong Chewatanakornkul [1 ]
Samornmas Kanngurn [2 ]
Wanwisa Maneechay [3 ]
Walawee Chaiyapan [1 ]
Surasak Sangkhathat [1 ]
机构
[1] Department of Surgery and Tumor Biology Research Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
[2] Anatomical Pathology Unit, Department of Pathology, Faculty of Medicine, Prince of Songkla Uni- versity, Hat Yai, Songkhla 90110, Thailand
[3] Central Molecular Research Laboratory, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
关键词
Gastrointestinal stromal tumor; Targeted therapy; Overall survival; Progress free survival; Progressive disease;
D O I
暂无
中图分类号
R735 [消化系肿瘤];
学科分类号
100214 ;
摘要
<Abstract>AIM: To review a single institutional experience in clinical management of gastrointestinal stromal tumors (GIST) and analyze for factors determining treatment outcome. METHODS: Clinicopathological data of patients with a diagnosis of GIST who were treated at our institute during November 2004 to September 2009 were retrospectively reviewed. RESULTS: Ninety-nine cases were included in the analysis. Primary tumor sites were at the stomach in and small bowel in 44% and 33%, respectively. Thirty-one cases already had metastasis at presentation and the most common metastatic site was the liver. Sixty-four cases (65%) were in the high-risk category. Surgical treatment was performed in 77 cases (78%), 3 of whomreceived upfront targeted therapy. Complete resection was achieved in 56 cases (73% of operative cases) and of whom 27 developed local recurrence or distant metastasis at a median duration of 2 years. Imatinib was given as a primary therapy in unresectable cases (25 cases) and as an adjuvant in cases with residual tumor (21 cases). Targeted therapy gave partial response in 7 cases (15%), stable disease in 27 cases (57%) and progressive disease in 13 cases (28%). Four-year overall survival was 74% (95% CI: 61%-83%). Univariate survival analysis found that low-risk tumor, gastric site, complete resection and response to imatinib were associated with better survival. CONCLUSION: The overall outcomes of GIST can be predicted by risk-categorization. Surgery alone may not be a curative treatment for GIST. Response to targeted therapy is a crucial survival determinant in these patients.
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页码:216 / 222
页数:7
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