DNA methylation signatures in circulating cell-free DNA as biomarkers for the early detection of cancer

被引：0
|
作者：
Junyun Wang [1 ]
Xiao Han [1 ,2 ]
Yingli Sun [1 ]
机构：
[1] Key Laboratory of Genomic and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences
[2] University of Chinese Academy of Sciences
来源：
Science China Life Sciences | 2017年 / 60卷 / 04期
基金：
中国国家自然科学基金;
关键词：
circulating cell-free DNA; DNA methylation; diagnostic markers; cancer detection;
D O I：
暂无
中图分类号：
R730.43 [实验室诊断];
学科分类号：
100214 ;
摘要：
Detecting cell-free DNA(cfDNA) or circulating tumor DNA(ctDNA) in plasma or serum could serve as a "liquid biopsy", which would be useful for numerous diagnostic applications. cfDNA methylation detection is one of the most promising approaches for cancer risk assessment. Here, we reviewed the literature related to the use of serum or plasma circulating cell-free DNA for cancer diagnosis in the early stage and their power as future biomarkers.
引用
收藏
页码：356 / 362
页数：7
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