Synthesis and Antibacterial Activities of 1,4-Disubstituted Phenyl-5-(halo-2-hydroxyphenyl)imino-1,2,3-triazole

According to the superposition principle of reinforcement of biological activities,24 novel 1,4disubstituted phenyl-5-(halo-2-hydroxyphenyl)imino-1,2,3-triazoles was synthesized and characterized by 1 H NMR,13 C NMR,elemental analysis and IR.All the target compounds were screened for their antibacterial potential in vitro against Monilia albican,Escherichia coli and Staphylococcus aureus.It was shown that all the compounds possessed efficient antibacterial activities at a concentration of 0.1 mg/mL,even at a concentration of 0.01 mg/mL,some of the compounds still exhibited antibacterial activities against Escherichia coli and Monilia albican.At last,the structure-activity relationship was discussed based on the antibacterial results.