Effect of Xingnaojing Injection(醒脑静注射液)on Hippocampal N-methyl-D-aspartic Acid Receptors of Focal Cerebral Ischemia in Rats

被引：0

作者：

沈思钰

蔡定芳

陈伟华

刘静

陈虎

应健

机构：

[1] Nanjing University

[2] Department of Traditional Chinese Medicine

[3] Jinling Hospital

[4] Nanjing

[5] Institute of Integrated Traditional and Western Medicine

[6] Huashan Hospital Affiliated to Fudan University

[7] Shanghai

[8] Shanghai

来源：

Chinese Journal of Integrated Traditional and Western Medicine | 2003年 / 01期

关键词：

Xingnaojing injection; focal cerebral ischemia; N-methyl-D-aspartic acid receptor; neuro-protection;

D O I：

暂无

中图分类号：

R743.33 [脑栓塞];

学科分类号：

摘要：

<正> Objective: To observe and elucidate the neuroprotective effect of Xingnaojing (XNJ) injection on hippocampal N-methyl-D-aspartic acid (NMDA) receptors of focal cerebral ischemia in rats. Methods: Cerebral ischemia was established by occluding the middle cerebral artery with an intraluminal suture technique in rats. Neurological deficit score, infarct volume and quantity of NMDA receptors were estimated in all groups and compared. Results: After being treated with XNJ, the score decreased in the initial 6 hours and infarct volume decreased in 24 hours. And within 24 hours, the quantity of NMDA receptors obviously decreased compared with the model group (P<0. 01) It indicated that XNJ could ameliorate neurological behavior of middle cerebral artery occlusion rats and down-regulate the expression of hippocampal NMDA receptors. Conclusion: The neuroprotective effect of XNJ on focal cerebral ischemia is possibly related to down-regulating the expression of NMDA receptors in rats.

引用

页码：49 / 52

页数：4

共 5 条

[1] Blocking the glycine-binding site of NMDA receptors prevents the progression of ischemic pathology induced by bilateral carotid artery occlusion in spontaneously hypertensive rats
Ohtani, K
Tanaka, H
Yasuda, H
Maruoka, Y
Kawabe, A
Nakamura, M
[J]. BRAIN RESEARCH, 2000, 871 (02) : 311 - 318
[2] Neurological impairment in rats after transient middle cerebral artery occlusion: a comparative study under various treatment paradigms[J] . Stefan Zausinger,Edwin Hungerhuber,Alexander Baethmann,Hanns-Jürgen Reulen,Robert Schmid-Elsaesser.Brain Research . 2000 (1)
[3] Neuroprotective therapy
Hickenbottom, SL
Grotta, J
[J]. SEMINARS IN NEUROLOGY, 1998, 18 (04) : 485 - 492
[4] MONOCLONAL-ANTIBODIES PREVENTING LEUKOCYTE ACTIVATION REDUCE EXPERIMENTAL NEUROLOGIC INJURY AND ENHANCE EFFICACY OF THROMBOLYTIC THERAPY
BOWES, MP
ROTHLEIN, R
FAGAN, SC
ZIVIN, JA
[J]. NEUROLOGY, 1995, 45 (04) : 815 - 819
[5] REVERSIBLE MIDDLE CEREBRAL-ARTERY OCCLUSION WITHOUT CRANIECTOMY IN RATS
LONGA, EZ
WEINSTEIN, PR
CARLSON, S
CUMMINS, R
[J]. STROKE, 1989, 20 (01) : 84 - 91

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