MUTATION AND ABNORMAL EXPRESSION OF P16INK4a INHEPATOCELLULAR CARCINOMA

被引：0
|
作者：
张胜亮
张耀铮
阎萍
高鹤立
机构：
来源：
Chinese Journal of Cancer Research | 1999年 / 04期
关键词：
Liver cancer; Tumor suppressor gene; p16INK4agene;
D O I：
暂无
中图分类号：
R735.7 [肝肿瘤];
学科分类号：
100214 ;
摘要：
Objective:To investigate the relationship betweenp16INK4a and primary hepatocellular carcinoma (HCC),especially hepatitis B-related HCC. Methods: p16INK4a andits protein in HCC were analyzed with PCR-SSCP and theimmunohistochemistry methods respectively. Results: Thepositive incidence of p16INK4 protein expressing in HCC waslower than that of normal liver tissue (P<0.05), and theabsence of p16INK4 protein was associated with HCCmetastasis (P<0.05). The low frequency of mutation ofp16INK4 exonl and exon2 upstream fragment was found inHCC. Conclusion: Absence of p16INK4 protein in HCC wasnot associated with HBV-infection.
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页码：3 / 5
页数：4
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