Investigation of nitroxoline-human serum albumin interactions by spectroscopic methods

被引：0

作者：

ZHANG Wan Ju ^{[1
,2
]}

XIONG Xu Jie ^{[1
]}

WANG Fang ^{[1
]}

LI Li ^{[1
]}

ZHANG Yan ^{[1
]}

XIAO Wen Ping ^{[1
]}

LIU Yi ^{[2
]}

机构：

[1] Hubei Key Laboratory for Processing and Application of Catalytic Materials, Huanggang Normal University

[2] State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University

来源：

Science China Chemistry | 2014年 / 57卷 / 12期

基金：

中国国家自然科学基金;

关键词：

nitroxoline; human serum albumin; spectroscopic methods; interaction;

D O I：

暂无

中图分类号：

R3411 [];

学科分类号：

1001 ;

摘要：

Nitroxoline is a wide spectrum antibacterial and is one of the most important urinary antiseptics.The interaction between nitroxoline and human serum albumin(HSA)has been investigated systematically by fluorescence spectroscopy,synchronous fluorescence,three-dimensional fluorescence,CD spectroscopy and UV-Vis absorption spectroscopy.The results indicated that the quenching of HSA by nitroxoline was static.The corresponding thermodynamic parameters △H,△S and △G calculated according to van’t Hoff equation revealed that the intermolecular forces acting between nitroxoline and HSA were mainly hydrogen bonding and van der Waals forces.The conformational changes in the interaction were studied by synchronous fluorescence,CD spectroscopy and three-dimensional fluorescence spectra which showed changes in the microenvironment and conformation of HSA.

引用

页码：1690 / 1695

页数：6

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