Design, synthesis and biological evaluation of biphenylurea derivatives as VEGFR-2 kinase inhibitors(Ⅱ)

被引：0

作者：

Guo-Rui Gao ^{[1
]}

Meng-Yuan Li ^{[2
,3
]}

Yong-Cong Lv ^{[4
]}

Su-Fen Cao ^{[1
]}

Lin-Jiang Tong ^{[2
]}

Li-Xin Wei ^{[3
]}

Jian Ding ^{[2
]}

Hua Xie ^{[2
]}

Wen-Hu Duan ^{[1
,4
]}

机构：

[1] School of Pharmacy, East China University of Science & Technology

[2] Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

[3] Pharmacology and Safety Evaluation Key Laboratory of Tibetan Medicine in Qinghai Province, Northwest Institute of Plateau Biology, Chinese Academy of Sciences

[4] Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

来源：

Chinese Chemical Letters | 2016年 / 27卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Angiogenesis; Kinase; Inhibitor; VEGFR-2;

D O I：

暂无

中图分类号：

TQ460.1 [基础理论];

学科分类号：

1007 ;

摘要：

Inhibition of VEGFR-2 signaling pathway is one of the most promising approaches for the treatment of cancer. In this paper, we reported the design, synthesis, and biological evaluation of a series of biphenylurea derivatives as VEGFR-2 inhibitors. Among these compounds, 39 exhibited potent inhibitory activity against VEGFR-2 both in vitro and in vivo. The antiangiogenesis activity of 39 was further confirmed by both tube formation assay and chick chorioallantoic membrane assay.

引用

页码：200 / 204

页数：5

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