Relationship between IRS-2G1057D variant and type 2 diabetes mellitus in Han population in Liaoning Province, China

被引：0
|
作者：
KONG Ling-fang
机构：
来源：
中华医学杂志(英文版) | 2005年 / 05期
关键词：
insulin receptor substrate-2 · type 2 diabetes mellitus · obesity · insulin resistance;
D O I：
暂无
中图分类号：
R587.1 [糖尿病];
学科分类号：
1002 ; 100201 ;
摘要：
The two major pathogeneses of type 2 diabetes mellitus (T2DM) are insulin resistance and insulin secretion deficiency. During recent years, researches on the molecular target sites of insulin resistance and the mechanism of the signal transduction has made great progress: especially, the study of insulin receptor substrate-2 (IRS-2). Human IRS-2 gene is located at 13q8.6. IRS-2G1057D is a replacement of G (glycine) by D (aspartic acid) at site 1057 of insulin receptor substrate-2, which is caused by simple nucleotide polymorphism. The role of this variant is still not clear. We detected IRS-2G1057D variant in Han population in Liaoning Province by measuring body mass index (BMI), waistline/hip ratio (WHR) and other parameters of insulin secretion, as well as insulin action to explore the relationship between IRS-2G1057D variant and T2DM.
引用
收藏
页码：415 / 417
页数：3
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