New limonoids isolated from the bark of Melia toosendan

被引：0
|
作者：
ZHANG Qiong [1 ]
ZHENG Qing-Hong [1 ]
SANG Yi-Shu [2 ]
SUNG Herman Ho-Yung [3 ]
MIN Zhi-Da [2 ]
机构：
[1] Department of Pharmaceutical Science, Shanxi Medical University
[2] Department of Natural Medicinal Chemistry, China Pharmaceutical University
[3] Department of Chemistry, Hong Kong University of Science and Technology
来源：
ChineseJournalofNaturalMedicines | 2018年 / 16卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Melia toosendan; Meliaceae; Limonoid; Toosendanin; Absolute configuration;
D O I：
暂无
中图分类号：
R284 [中药化学];
学科分类号：
摘要：
Two new limonoids, 12-ethoxynimbolinins G and H(compounds 1 and 2), and one known compound, toosendanin(Chuanliansu)(compound 3), were isolated from the bark of Melia toosendan. Their structures were elucidated by spectroscopic analysis and X-ray techniques. The absolute configuration of toosendanin(3) was established by single-crystal X-ray diffraction. Compounds 1-3 were evaluated for their cytotoxicity against five tumor cell lines.
引用
收藏
页码：946 / 950
页数：5
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