Syntheses and Anti-inflammatory Action of (η-C5H5)2Ti(Cin)2 and (η-C5H5)2Ti(Tzea)2

Two new complexes (Cp) 2Ti(Cin) 2 and (Cp) 2Ti(Tzea) 2 (Cp= Cyclopentadienyl η 5 C 5H 5) have been synthesized in THF by the reaction of HCin (Cincofen, 2 phenylquinoline 4 carboxylic acid) or HTzea (5 phenyltetrazolyl 2 ethanoic acid) with (Cp) 2TiCl 2, and characterized by elemental analyses, IR, 1H NMR and 13 C NMR, UV spectra, molar conductivity, TG DTA. In the complexes the carboxyl groups are coordinated to Ti(IV) in a monodentate manner. The inhibitory actions of the complexes on mice ear tumefaction caused by croton oil and the rat foot granulation growth produced by cotton wool are higher than those of the corresponding ligands HCin, HTzea and [(Cp) 2TiCl 2], while their toxicities are lower than those of the free ligands.