Development of novel therapies for Huntington's disease:hope and challenge

被引：0
|
作者：
Zheng-hong QIN~(2
~3Laboratory of Cellular Neurobiology
~4Molecular Neurogenetics Unit
机构：
来源：
Acta Pharmacologica Sinica | 2005年 / 02期
基金：
中国国家自然科学基金;
关键词：
Huntington disease; huntingtin; aggregates; caspases; nerve growth factors; cell transplantation; coenzyme Q10;
D O I：
暂无
中图分类号：
R742.2 [舞蹈病];
学科分类号：
1002 ;
摘要：
Huntington’s disease(HD)is an autosomal dominant neurological disease.It is afatal neurological disorder affecting 5-10 out of 10000 people.While there areintensive research efforts focusing on uncovering molecular mechanisms of thepathogenesis of HD,a number of studies have begun to look for effective thera-pies for HD.There is a large body of encouraging news on novel therapeuticdevelopments.The present paper reviews drugs used for symptomatic treatmentof HD and experimental therapies targeting HD molecular pathology.
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页码：129 / 142
页数：14
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