The relationship between chronic PTSD,cortical volumetry and white matter microstructure among Australian combat veterans

Background: Posttraumatic stress disorder(PTSD) has been associated with volumetric and white matter microstructural changes among general and veteran populations. However, regions implicated have greatly varied and often conflict between studies, potentially due to confounding comorbidities within samples. This study compared grey matter volume and white matter microstructure among Australian combat veterans with and without a lifetime diagnosis of PTSD, in a homogenous sample assessed for known confounding comorbidities.Methods: Sixty-eight male trauma-exposed veterans(16 PTSD-diagnosed; mean age 69 years) completed a battery of psychometric assessments and underwent magnetic resonance and diffusion tensor imaging. Analyses included tractbased spatial statistics, voxel-wise analyses, diffusion connectome-based group-wise analysis, and volumetric analysis.Results: Significantly smaller grey matter volumes were observed in the left prefrontal cortex(P=0.026), bilateral middle frontal gyrus(P=0.021), and left anterior insula(P=0.048) in the PTSD group compared to controls. Significant negative correlations were found between PTSD symptom severity and fractional anisotropy values in the left corticospinal tract(R2=0.34, P=0.024) and left inferior cerebellar peduncle(R2=0.62, P=0.016). No connectome-based differences in white matter properties were observed.Conclusions: Findings from this study reinforce reports of white matter alterations, as indicated by reduced fractional anisotropy values, in relation to PTSD symptom severity, as well as patterns of reduced volume in the prefrontal cortex.These results contribute to the developing profile of neuroanatomical differences uniquely attributable to veterans who suffer from chronic PTSD.