新RNA编辑技术CRISPR-Cas13

被引：0

作者：

刘彦均 ^{[1
]}

陈志胜 ^{[1
]}

机构：

[1] 佛山科学技术学院生命科学与工程学院

来源：

生物技术进展 | 2019年 / 06期

关键词：

CRISPR-Cas13系统; HEPN结构域; RNA干扰; Type VI-A/B/D;

D O I：

10.19586/j.2095-2341.2019.0054

中图分类号：

Q78 [基因工程（遗传工程）];

学科分类号：

071007 ; 0836 ; 090102 ;

摘要：

CRISPR-Cas13系统(clustered regularly interspaced short palindromic repeats associated Cas system, CRISPR-Cas)是一种快速、高效、精准的新型RNA编辑工具,具有易于设计、结构简单、操作方便、特异性强的特点。综述了CRISPR-Cas13在CRISPR分类系统中的地位、CRISPR-Cas13的结构基础以及作用机制、与其他RNA水平调节方法的比较以及目前的应用前景,以期为相关研究提供参考。

引用

页码：571 / 578

页数：8

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