Molecular Cloning of a Novel Bovine Homologue of the Drosophila Tumor Suppressor Gene,Lats

Pervious studies demonstrate that lats, also known as warts, is a tumor suppressor gene in Drosophila . Mutations of lats lead to an increase in cell number and organ size in Drosophila, indicating lats may be involved in organ size control. Furthermore, the high conservation of sequence and tumor suppression function of lats between Drosophila and human suggests that it may be also involved in organ size control of higher animals . So here we isolated the bovine homologue of Drosophila lats. Sequence analysis indicates the bovine LATS1 to be very similar to other lats proteins.