Primary nasopharyngeal non-Hodgkin lymphoma and its relationship with Epstein-Barr virus infection

被引：0
|
作者：
张彬
宗永生
何洁华
钟碧玲
林素暇
机构：
[1] Department of Pathology
[2] Sun Yat-sen Medical College
[3] Sun Yat-sen University
[4] Guangzhou 510089
[5] China
来源：
中华医学杂志(英文版) | 2003年 / 06期
关键词：
nasopharynx·lymphoma; non-Hodgkin·immunophenotype ·Epstein-Barr virus;
D O I：
暂无
中图分类号：
R739.63 [咽肿瘤];
学科分类号：
100214 ;
摘要：
Objectives To investigate the immunophenotypes of primary nasopharyngeal non-Hodgkin lymphoma (NPL) and their relationship to Epstein-Barr virus (EBV) infection.Methods The clinical data and biopsies of 73 patients with NPL were collected in Guangzhou. In situ hybridization was performed to detect the EBV-encoded small non-polyadenylated nuclear RNAs (EBERs) on biopsy slides. Immunohistochemistry was used to classify the immunophenotypes of NPL and detect EBV antigen expression.Results Forty-four (60.27%) of the 73 NPLs were of B cell lineage (CD79α+/CD3-/CD56-) while the 29 others (39. 73%) were of non-B cell lineage. Seventy-three NPLs could be classified into 3 major immunophenotypes: B cell (CD79α+/CD3-/CD56-, 44 cases), peripheral T cell (CD79α-/ CD3+/CD56-, 22) and NK/T cell (CD79α-/CD3+/CD56+, 7). The percentages of EBV infection differed among the 3 major immunophenotypes (B cell: 11. 36%, 5/44; peripheral T cell: 81. 82%, 18/22; NK/T cell: 100% ,7/7). Both CD56-ositive and CD56-negative imm
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页码：115 / 119
页数：5
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