TGFβ and Hypoxia Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment

被引：0

作者：

Lauren K DUNN ^{[1
,2
]}

Pierrick GJ FOURNIER ^{[1
]}

Khalid S MOHAMMAD ^{[1
]}

C Ryan MCKENNA ^{[1
]}

Holly W DAVIS ^{[1
]}

Maria NIEWOLNA ^{[1
]}

John M CHIRGWIN ^{[1
,2
]}

Theresa A GUISE ^{[1
]}

机构：

[1] Department of Medicine Division of Endocrinology University of Virginia

[2] Department of Biochemistry and Molecular Genetics University of

来源：

中国肺癌杂志 | 2009年 / 12卷 / 06期

关键词：

TGF; and Hypoxia Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment;

D O I：

暂无

中图分类号：

R737.9 [乳腺肿瘤]; R738.1 [骨骼肿瘤];

学科分类号：

摘要：

<正>Breast cancers frequently metastasize to bone, a site of hypoxia and high concentrations of active TGFβ. Skeletal metastases involve interactions between tumor and bone cells driven by locally secreted proteins, many of

引用

页码：32 / 32

页数：1