Antibody mediated rejection causing dialysis dependent acute renal failure,partially rescued with Eculizumab

被引：0

作者：

Mark J Lerman ^{[1
]}

Afzal Nikaein ^{[2
]}

Michael Kuperman ^{[3
]}

机构：

[1] Transplant Services at Medical City Dallas Hospital

[2] Texas Medical Specialty,Inc

[3] John Hopkins University Medical

来源：

实用器官移植电子杂志 | 2018年 / 6卷 / 04期

关键词：

AMR; DSA; Antibody mediated rejection causing dialysis dependent acute renal failure; partially rescued with Eculizumab;

D O I：

暂无

中图分类号：

R699.2 [肾脏手术];

学科分类号：

摘要：

抗体介导排斥反应(AMR)是导致移植肾失功的主要原因。AMR的诊断依据为患者存在供者特异性抗体(DSA)、移植肾活检标本管周毛细血管C4d染色阳性以及急性排斥反应的组织学表现。目前AMR的治疗方法包括血浆置换、静脉免疫球蛋白和抗CD20治疗。这些方法对严重的AMR没有效果。Eculizumab是一种人源化的抗C5单克隆抗体,能抑制补体末端的激活。最新的研究已经表明Eculizumab能够用于治疗严重的AMR或者预防AMR。本文介绍了一例应用Eculizumab治疗有效的AMR,而该病例对传统的治疗AMR方法无效。

引用

页码：270 / 272

页数：3

共 4 条

[1] Eculizumab for Treatment of Refractory Antibody-Mediated Rejection in Kidney Transplant Patients: A Single-Center Experience
Yelken, B.
Arpali, E.
Gorcin, S.
Kocak, B.
Karatas, C.
Demiralp, E.
Turkmen, A.
[J]. TRANSPLANTATION PROCEEDINGS, 2015, 47 (06) : 1754 - 1759
[2] Diagnosis and Treatment of Acute Humoral Kidney Allograft Rejection
Gomes, A. M.
Pedroso, S.
Martins, L. S.
Malheiro, J.
Viscayno, J. R.
Santos, J.
Dias, L.
Henriques, A. C.
Sarmento, A. M.
Cabrita, A.
[J]. TRANSPLANTATION PROCEEDINGS, 2009, 41 (03) : 855 - 858
[3] Donor-Specific Antibodies Against HLA, MICA, and GSTT1 in Patients with Allograft Rejection and C4d Deposition in Renal Biopsies
Alvarez-Marquez, Antonia
Aguliera, Isabel
Gentil, Miguel A.
Caro, Joe L.
Bernal, Gabriel
Alonso, Jorge Fernandez
Acevedo, Maria J.
Cabello, Virginia
Wichmann, Ingeborg
Gonzalez-Escribano, Maria F.
Nunez-Roldan, Antonio
[J]. TRANSPLANTATION, 2009, 87 (01) : 94 - 99
[4] Therapy with plasmapheresis and intravenous immunoglobulin for acute humoral rejection in kidney transplantation
Ibernón, M
Gil-Vernet, S
Carrera, M
Serón, D
Moreso, F
Bestard, O
Cruzado, JM
Grinyó, JM
[J]. TRANSPLANTATION PROCEEDINGS, 2005, 37 (09) : 3743 - 3745

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