Synthesis and biological activity of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives

被引：0
|
作者：
Jing-Qian Huo [1 ]
Liu-Yong Ma [2 ]
Zhe Zhang [1 ]
Zhi-Jin Fan [2 ,3 ]
Jin-Lin Zhang [1 ]
Tetyana V.Beryozkina [4 ]
Vasiliy A.Bakulev [4 ]
机构：
[1] College of Plant Protection, Agricultural University of Hebei
[2] State Key Laboratory of Elemento-Organic Chemistry, Nankai University
[3] Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University
[4] The Ural Federal University Named after the First President of Russia B.N.Yeltsin
来源：
Chinese Chemical Letters | 2016年 / 27卷 / 09期
基金：
对外科技合作项目（国际科技项目）; 中国国家自然科学基金;
关键词：
Amides derivative; Pyrazole; Furan; Synthesis; Herbicidal activity; Fungicidal activity;
D O I：
暂无
中图分类号：
O623.626 [含氮功能衍生物];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives were designed and synthesized. Their structures were confirmed by1H NMR,13C NMR and HRMS. All title compounds were evaluated for their herbicidal and antifungal activities. Preliminary bioassay results indicated that the title compounds showed good to moderate herbicidal activity at 1000 mg/L. Compound 6q presented the best activity against Digitaria sanguinalis(L) Scop., Amaranthus retroflexus L. and Arabidopsis thaliana with an inhibition degree of five. Compound 6d also showed an inhibition degree of five against D. sanguinalis.In addition, at 50 mg/L, most compounds exhibited good in vitro antifungal activity against Sclerotinia sclerotiorum, with compound 6c showing over 90% antifungal activity against S. sclerotiorum and Pellicularia sasakii.
引用
收藏
页码：1547 / 1550
页数：4
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