SEMA3A蛋白功能研究进展

被引：1
|
作者：
戴文婷
蒋最明
顾敏
机构：
[1] 中南大学湘雅医学院附属株洲医院临床检验中心,株洲
来源：
国际遗传学杂志 | 2020年 / 43卷 / 06期
关键词：
信号素3A; 蛋白功能;
D O I：
暂无
中图分类号：
R341 [];
学科分类号：
摘要：
SEMA3A作为神经轴突发育的一个关键信号蛋白, 参与多种生理过程。SEMA3A是一种分泌性蛋白, 属于3号信号素(class-3 semaphorins)家族, 通过结合NRP1、NRP2和PLXN A复合物受体参与轴突排斥、树突分支、突触形成和神经元迁移过程。SEMA3A是神经元迁移信号的主要组成部分;SEMA3A在免疫反应的所有阶段被认为是一种有效的免疫调节剂;SEMA3A通过对成骨细胞和破骨细胞的作用来调节骨重塑, 通过抑制骨吸收和增加骨形成发挥了骨保护作用;SEMA3A通过NRP1和Plexin D1在心血管发育中起着重要作用。
引用
收藏
页码：349 / 352
页数：4
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