Physostigmine blocked nicotinic acetylcholine receptors in rat sympathetic ganglion neurons

被引：0
|
作者：
郑建全 [1 ]
何湘平 [1 ]
杨爱珍 [1 ]
刘传缋 [1 ]
机构：
[1] 军事医学科学院毒物药物研究所
来源：
Acta Pharmacologica Sinica | 1997年 / 06期
关键词：
交感神经节; 烟碱受体; 毒扁豆碱; 变构调节; 膜片箝技术;
D O I：
暂无
中图分类号：
R338 [神经生理学];
学科分类号：
0710 ; 071006 ;
摘要：
目的：研究毒扁豆碱阻断交感节神经元烟碱受体的作用机理．方法：以培养的新生大鼠颈上交感节神经元为标本，使用全细胞膜片箝技术，观察毒扁豆碱对交感节烟碱受体选择性激动剂ＤＭＰＰ诱发电流的影响．结果：毒扁豆碱（５－２０μｍｏｌ·Ｌ－１）以浓度依赖性方式抑制ＤＭＰＰ诱发电流，促进诱发电流的衰减，其抑制作用没有电压依赖性，毒扁豆碱２００μｍｏｌ·Ｌ－１不能激活烟碱受体．结论：与骨骼肌烟碱受体相比，交感神经元烟碱受体表现出不同的药理学特性．毒扁豆碱通过作用于变构位点抑制交感神经元烟碱受体，不影响其开放的离子通道和激动剂结合位点．
引用
收藏
页码：28 / 31
页数：4
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