Effects of PKCa antisense RNA on human breast cancer cell proliferation and expression of cyclinD1 and CDK4

被引：0
|
作者：
SANG Jianli WANG YongchaoLaboratory of Cell Biology
机构：
来源：
Science Bulletin | 1999年 / 12期
关键词：
breast cancer; PKCα; cell proliferation; cyclinD1; CDK4;
D O I：
暂无
中图分类号：
R737.9 [乳腺肿瘤];
学科分类号：
100214 ;
摘要：
The role of PKCα in human breast cancer cell proliferation and expression of cyclinD1 and CDK4 has been investigated using inhibition of PKCα expression by its antisense RNA. When PKCα expression was inhibited the rate of cell proliferation decreased apparently and the levels of cyclinD1 and CDK4 mRNA were lower than the control. The results showed that PKCα, a key member of signal transduction system, played an important role in human breast cancer cell proliferation and had a close relationship with expression of cyclinD1 and CDK4 which control start of cell cycle.
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页码：1110 / 1114
页数：5
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