CLINICAL VALUE OF URINARY AND SERUM PSEUDOURIDINE IN DIAGNOSIS AND MONITORING OF PRIMARY LIVER CANCER

被引：0
|
作者：
屠振兴 [1 ]
许圣献 [1 ]
吴孟超 [1 ]
机构：
[1] Institute of Hepatobiliary Surgery. Changhai Hospital. Shanghai 200433
来源：
中华医学杂志(英文版) | 1995年 / 03期
关键词：
CLINICAL VALUE OF URINARY AND SERUM PSEUDOURIDINE IN DIAGNOSIS AND MONITORING OF PRIMARY LIVER CANCER; than;
D O I：
暂无
中图分类号：
R735.7 [肝肿瘤];
学科分类号：
100214 ;
摘要：
Urinary and serum pseudouridine concentrations were determined by high-performance liquid chromatography in 80 patients with primary liver cancer, 32 with benign space occupying lesions of the liver, 42 with liver cirrhosis and 40 healthy subjects. Their mean urinary and serum pseudouridine levels were 39.2=11.5 nmol / /μmol creatinine and 3.4 ± 1.3 μmol / L, 24.5 = 5.4 nmol / μmol creatinine and 2.5 = 0.5 μmol / L, 22.8 ± 7.8 nmol / μmol creatinine and 2.3 = 0.4 μmol / L, 26.4 ± 4.6 nmol / μmol creatinine and 2.3 = 0.4 μmol / L, respectively. Exceeding the mean plus 2SD of pseudouridine of healthy control was considered as positive value for the diagnosis of primary liver cancer. Thus the positivity of urinary and serum pseudouridine in hepatoma was 71.3% and 70.0%, respectively. The positive rate of combined pseudouridine and alpha-fetoprotein assay was 91.3% in patients with hepatoma. Besides, pseudouridine levels could elevate before positive localization and reduce to normal levels after
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页码：46 / 50
页数：5
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