pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment

被引：0
|
作者：
Ke-Ni Yang [1 ,2 ]
Chun-Qiu Zhang [2 ]
Wei Wang [1 ]
Paul C.Wang [3 ]
Jian-Ping Zhou [1 ]
Xing-Jie Liang [2 ]
机构：
[1] State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University
[2] CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences
[3] Laboratory of Molecular Imaging, Department of Radiology, Howard University
来源：
Cancer Biology & Medicine | 2014年 / 01期
基金：
中国国家自然科学基金;
关键词：
Mesoporous silica nanoparticles; pH-responsive; controlled drug release; drug delivery systems; antineoplastic protocols;
D O I：
暂无
中图分类号：
R730.5 [肿瘤治疗学];
学科分类号：
100214 ;
摘要：
In the fight against cancer, controlled drug delivery systems have emerged to enhance the therapeutic efficacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles(MSNs) with a functional surface possess obvious advantages and were thus rapidly developed for cancer treatment. Many stimuli-responsive materials, such as nanoparticles, polymers, and inorganic materials, have been applied as caps and gatekeepers to control drug release from MSNs. This review presents an overview of the recent progress in the production of pH-responsive MSNs based on the pH gradient between normal tissues and the tumor microenvironment. Four main categories of gatekeepers can respond to acidic conditions. These categories will be described in detail.
引用
收藏
页码：34 / 43
页数：10
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