Association of HLA-DRB1, DQB1 Alleles with Chronic Urticaria

被引：0
|
作者：
陈静
谭志建
李家文
熊平
机构：
[1] Huangzhong University of Science and Technology Wuhan 430022
[2] Tongji Medical College
[3] Union Hospital
[4] China
[5] Department of Dermatology
[6] Huangzhong University of Science and Technology
来源：
Current Medical Science | 2005年 / 03期
关键词：
urticaria; chronic; genes; MHC class Ⅱ; polymerase chain reaction-sequence specific primer;
D O I：
暂无
中图分类号：
R511.2 [风疹];
学科分类号：
100401 ;
摘要：
In order to investigate the association of genotypes of HLA-DRB1 and HLA-DQB1 alleles with the genetic susceptibility of chronic urticaria (CU), genotypes of HLA-DRB1 and HLA-DQB1 genes were detected by polymerase chain reactions with sequence-specific primers (PCR-SSP) in 42 patients with CU (19 men and 23 women, mean age 30.67±12.45 y old as well as 193 racially matched healthy persons in ethnic Han from Hubei provinece. Gene frequencies of HLA-DRB1*12, *0901 (RR=3.11, χ2=7.579, P=0.006; RR=2.47, χ2=5.684, P=0.017) were significantly increased in CU patients as compared with that in healthy people. Gene frequencies of HLA-DQB1*05 (RR=0.26, χ2=6.683, P=0.01) were significantly decreased in CU patients. It was suggested that CU was found strongly associated with HLA-DRB1*12, *0901 and HLA-DQB1*05, the former might be the genetic markers for susceptibility to CU, but the latter might play a resistive role.
引用
收藏
页码：354 / 356
页数：3
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